CLINICAL STUDIES ON ISOCITRIC DEHYDROGENASE

Triphosphopyridine nucleotide linked isocitric dehydrogenase in bacteria.

The conversion of isocitric acid to alpha-ketoglutarate has been demonstrated both in animal tissues (Martius, 1937; Krebs and Johnson, 1937; Adler et al., 1939; Ochoa, 1948) and in yeast (Kornberg and Pricer, 1951; Foulkes, 1951). Triphosphopyridine nucleotide was first implicated as a specific coenzyme for this reaction by Adler et al. (1939). Recently Kornberg and Pricer (1951) found in yeas...

Diphosphopyridine nucleotide isocitric dehydrogenase from animal tissues.

Serum transaminases and isocitric dehydrogenase in kwashiorkor.

Serum glutamic oxalacetic transaminase (G-OT), glutamic-pyruvic transaminase (G-PT), and isocitric dehydrogenase (ICD) have been estimated in six groups of subjects, namely, normal British adults, normal Nigerian adults, undernourished Nigerian adults and children, Nigerian children with florid protein malnutrition (kwashiorkor), and cases of protein malnutrition after treatment. The normal ran...

Enzyme systems in the mycobacteria. I. The isocitric dehydrogenase.

Studies on Succinic Dehydrogenase

About 2 years ago the author reported that the activity of purified preparations of succinic dehydrogenase is enhanced by phosphate buffer (2). This enhancement was dependent upon the phosphate concentration and appeared to be relatively specific for phosphate, since other buffers, such as Tris,l imidazole, histidine, glycylglycine, and arsenate did not induce it (2, 3). Arsenate, in fact, inte...